Rheumatoid Arthritis in the Knee: Causes and Treatment

Rheumatoid Arthritis in the Knee: Causes and Treatment

Rheumatoid arthritis (RA) is a complex autoimmune disease that wreaks havoc on the body’s joints, causing pain, inflammation, and reduced mobility. In this article, we’ll delve into the specifics of how this condition affects one of the most crucial joints in the body – the knee. So, if you or a loved one are dealing with rheumatoid arthritis in the knee, read on to find valuable insights, practical tips, and a sense of community in managing this challenging condition.

Understanding Rheumatoid Arthritis

Understanding Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a chronic autoimmune disease that primarily affects the joints. It causes inflammation, pain, and potentially joint damage throughout the body. Autoimmune diseases occur when the body’s immune system, which is designed to protect against harmful invaders like bacteria and viruses, mistakenly attacks healthy tissues.

In the case of RA, the immune system targets the synovium, which is the lining of the membranes that surround the joints. This leads to inflammation in the synovium, causing swelling, pain, stiffness, and warmth in the affected joints. Over time, if left untreated, this inflammation can lead to joint damage, deformities, and loss of function.

Symptoms of Rheumatoid Arthritis in the Knee

Rheumatoid arthritis (RA) can affect any joint in the body, including the knees. When RA affects the knees, it can cause a range of symptoms that can vary in severity. Some common symptoms of rheumatoid arthritis in the knee include:

  • Pain: Persistent pain in the knees, which might be described as aching, throbbing, or sharp. The pain can vary in intensity and may be worse during certain activities or after periods of rest.
  • Swelling: Inflammation in the knee joint can lead to visible swelling and a feeling of fullness or tightness in the knee area. This swelling might also make the knee feel warm to the touch.
  • Stiffness: Stiffness in the knees, especially after periods of inactivity like waking up in the morning or sitting for extended periods. This stiffness can make it difficult to move the knees smoothly and comfortably.
  • Limited Range of Motion: RA-related inflammation can restrict the normal range of motion in the knee joint. This can make bending or straightening the knee fully challenging and may lead to a feeling of joint “locking.”
  • Weakness: Muscles around the knee might weaken due to pain and inflammation, leading to a sense of instability or difficulty in bearing weight on the affected leg.
  • Crepitus: Some people might experience a crackling or grinding sensation (crepitus) when moving the knee joint due to the roughened joint surfaces caused by inflammation.
  • Fatigue: RA is often associated with general fatigue, and this fatigue can worsen when the knees are affected, making activities that involve walking or standing more tiring.
  • Joint Deformities: Over time, if RA is not well managed, it can lead to joint deformities. This might include changes in the alignment of the knees or the formation of nodules around the joint.

Causes of Rheumatoid Arthritis

The exact cause of rheumatoid arthritis (RA) is not fully understood, but it is believed to result from a combination of genetic, environmental, and immunological factors. Here’s a breakdown of these factors:

  • Genetic Predisposition: Genetic factors play a significant role in the development of RA. Certain genes are associated with an increased risk of developing the disease. For example, variations in the HLA-DRB1 gene are strongly linked to an elevated risk of RA. However, having these genetic markers doesn’t guarantee that an individual will develop the disease.
  • Autoimmune Response: RA is classified as an autoimmune disease. Autoimmune diseases occur when the immune system, which is designed to protect the body from infections, mistakenly attacks its healthy tissues. In RA, the immune system targets the synovium (the lining of the membranes that surround the joints), leading to chronic inflammation.
  • Environmental Triggers: While genetics play a role, environmental factors are also thought to trigger the autoimmune response in people who are genetically predisposed to RA. Potential triggers might include infections (e.g., viral or bacterial infections) that activate the immune system and lead to an abnormal immune response.
  • Hormones: Hormones, particularly sex hormones like estrogen, may influence the risk of developing RA. Women are more likely to develop RA than men, and the disease often goes into remission during pregnancy (when estrogen levels are high) and worsens after childbirth (when estrogen levels drop).
  • Smoking: Smoking tobacco is one of the most well-established environmental risk factors for developing RA. It not only increases the risk of developing the disease but also exacerbates its severity.

Diagnosis and Medical Evaluation

Diagnosis and Medical Evaluation

Diagnosing rheumatoid arthritis (RA) involves a combination of medical history, physical examination, laboratory tests, and imaging studies. A rheumatologist, a medical doctor who specializes in diagnosing and treating autoimmune and inflammatory conditions, is often involved in the diagnosis and management of RA. Here’s an overview of the diagnostic process:

1. Medical History: Your healthcare provider will ask you about your symptoms, including the nature and location of joint pain, swelling, stiffness, and any other symptoms you might be experiencing. They will also inquire about the duration of symptoms and how they affect your daily life.

2. Physical Examination: During the physical examination, the doctor will assess the affected joints for signs of inflammation, such as swelling, tenderness, warmth, and limited range of motion. They will also look for potential signs of other autoimmune conditions.

3. Laboratory Tests: Several blood tests can aid in diagnosing RA and ruling out other conditions with similar symptoms. Common blood tests include:

  • Rheumatoid Factor (RF): This antibody is often present in people with RA, though its presence is not exclusive to RA.
  • Anti-Cyclic Citrullinated Peptide (anti-CCP) Antibodies: These antibodies are more specific to RA and can help confirm the diagnosis.
  • Erythrocyte Sedimentation Rate (ESR) and C-Reactive Protein (CRP): Elevated levels of these markers indicate inflammation in the body, which is common in RA.
  • Complete Blood Count (CBC): Anemia (low red blood cell count) is often associated with RA and might be detected through a CBC.

Treatment Options

Treatment for rheumatoid arthritis (RA) aims to reduce inflammation, alleviate pain, slow down disease progression, and improve overall quality of life. The treatment approach often involves a combination of medications, lifestyle changes, and other interventions. Here are the main treatment options for RA:

1. Medications: Several types of medications are used to manage RA symptoms and modify the course of the disease:

  • Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): These drugs help relieve pain and inflammation. They are often used for short-term symptom relief.
  • Disease-Modifying Antirheumatic Drugs (DMARDs): DMARDs are the cornerstone of RA treatment. They aim to slow down disease progression and prevent joint damage. Conventional DMARDs include methotrexate, sulfasalazine, and leflunomide.
  • Biologic DMARDs: These are a newer class of medications that specifically target components of the immune system responsible for RA inflammation. Examples include TNF inhibitors, IL-6 inhibitors, and B-cell inhibitors.
  • Janus Kinase (JAK) Inhibitors: These medications block certain enzymes involved in the immune response. They are often used when other treatments are not effective.
  • Corticosteroids: These powerful anti-inflammatory drugs can provide quick relief from symptoms. They are often used in low doses and for short periods due to potential side effects.

2. Lifestyle Changes:

  • Exercise: Regular physical activity can help maintain joint flexibility, strengthen muscles, and improve overall well-being. Consult a physical therapist for tailored exercise recommendations.
  • Diet: A balanced diet rich in fruits, vegetables, whole grains, and lean proteins can help support overall health. Omega-3 fatty acids found in fish may have anti-inflammatory effects.
  • Weight Management: Maintaining a healthy weight reduces stress on joints, especially weight-bearing ones like the knees.
  • Joint Protection Techniques: Learning techniques to protect your joints during daily activities can help minimize strain and discomfort.

3. Physical and Occupational Therapy: Physical therapists can design exercise programs to improve joint function, mobility, and muscle strength. Occupational therapists can help you learn techniques to perform daily activities with less strain on your joints.

Surgical Interventions

Surgical Interventions

When non-surgical treatments fall short, surgical interventions step in. In severe cases of knee joint damage, surgical options like synovectomy (removing the inflamed lining) or total knee replacement may be considered.

The latter involves replacing the damaged joint with an artificial one, allowing for improved mobility and reduced pain.

Preventing Rheumatoid Arthritis in the Knee

Here are some general guidelines:

1. Maintain a Healthy Lifestyle:

  • Eat a Balanced Diet: Consume a diet rich in fruits, vegetables, whole grains, lean proteins, and healthy fats. Omega-3 fatty acids found in fish, flaxseeds, and walnuts may have anti-inflammatory effects.
  • Maintain a Healthy Weight: Excess weight can strain joints, including the knees. Maintaining a healthy weight can help reduce stress on your joints.
  • Exercise Regularly: Engaging in regular physical activity can support joint health, maintain flexibility, and strengthen muscles. Low-impact exercises like swimming, cycling, and walking can be gentle on the knees.
  • Don’t Smoke: Smoking is a known risk factor for developing RA, and it can worsen the severity of the disease.

2. Monitor Your Health:

  • Know Your Family History: If RA runs in your family, be aware of your genetic predisposition and potential risk factors.
  • Regular Check-ups: Stay current with routine medical check-ups and screenings. Early detection and intervention can make a difference in managing RA.

3. Reduce Stress:

  • Practice Stress Management: Chronic stress might impact the immune system. Engage in relaxation techniques, mindfulness, meditation, yoga, or hobbies that help you manage stress.


Rheumatoid arthritis in the knee is a formidable challenge, but armed with knowledge and a proactive approach, its impact can be mitigated. Remember that you’re not alone – a supportive medical team, lifestyle adjustments, and a strong support network can help you navigate the journey ahead. Together, we can make strides toward a better quality of life for individuals with rheumatoid arthritis.

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